In partnership with EdgeBio, VH Bio offers a comprehensive start-to-finish solution for all your next generation sequencing requirements:

• Consultation on experimental design
• Sample QC and library preparation
• Data analysis and customised bioinformatics support
• Data analysis and visualisation
• Integration
• Development
• Consulting services for all NGS platforms including 454, Illumina, SOLiD and Ion Torrent

Applications include:

Exome & Targeted Resequencing & Analysis

Targeted resequencing allows scientists to capture or target only the regions of interest of the human genome and then use high-throughput sequencing to assess the genetic variation within the captured DNA fragments. Click Exome & Targeted Resequencing & Analysis for more information.

Whole Transcriptome Sequencing & Analysis

Transcriptome analysis is of growing importance in understanding how altered expression of genetic variants contributes to complex diseases such as cancer, diabetes, and heart disease.  Analysis of genome-wide differential RNA expression provides researchers with greater insights into biological pathways and molecular mechanisms that regulate cell fate, development, and disease progression. Click Whole Transcriptome Sequencing & Analysis for more information.

Small RNA Sequencing & Analysis

Recently discovered families of small non-coding RNA have yield new insights for understanding gene regulation at the transcriptional and post-transcriptional level. Small non-coding RNAs are typically only 18-40 nucleotides in length; however their effect on cellular processes is profound. Click Small RNA Sequencing & Analysis for more information.

Methylation Sequencing & Analysis

Recently discovered families of small non-coding RNA have yield new insights for understanding gene regulation at the transcriptional and post-transcriptional level. Small non-coding RNAs are typically only 18-40 nucleotides in length; however their effect on cellular processes is profound. Click Methylation Sequencing & Analysis for more information.

Chromatin Immunoprecipitation Sequencing (ChIP-Seq) & Analysis

Chromatin immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a particular protein of interest. This technique gives a picture of the protein-DNA interactions involved in gene regulation or chromatin organization. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. Click Chromatin Immunoprecipitation Sequencing (ChIP-Seq) & Analysis for more information.

Whole Genome Resequencing

Genomes of all sizes, from microbes to mammals and plants, can be sequenced at a reasonable price with high throughput sequencing. Structural variation including SNPs and Indels can be indentified and catalogued.

Bioinformatics

Data analysis is a critical component of a Next Generation sequencing project. Our Bioinformatics team can help you reduce the time from data to results by offering customised bioinformatics solutions tailored to your specific needs. We leverage robust analysis pipelines for next generation sequencing platforms including 454, Illumina and SOLiD. We have solutions for many popular applications such as exome resequencing, microRNA, metagenomics, RNA-Seq, ChIP-Seq and whole genome sequencing. We take advantage of cloud and other HPC techniques to cost effectively support large scale scientific computing endeavours, data workflows and smaller scale customised data analysis shortening the time from experiment to results.

Pricing is dependent on organism and desired project design. For further information please contact our Molecular Biology Product Manager, Catherine Mair (email: cmair@vhbio.com or tel: +44 (0)191 495 8211).