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Request Your Free ZipScript ™ Sample

ZipScript is a new
One-Step RT-qPCR mix
from Enzymatics Inc.

SGS - inspection, verification, testing; certifica
British Society for Immunology
British Society for Histocompatibility & Immunogen
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Fragile X Testing
Asuragen's AmplideX® FMR1 and mPCR reagents employ an innovative PCR-only approach for the detection of methylation status in the FMR1 gene. These reagents reveal the extent of methylation of each individual allele in both male and female samples, and thus eliminate the need to run tedious and time consuming Southern blots.
Kit Features
  • Eliminates the need for Southern blot analysis
  • Amplifies and detects normal, intermediate, premutation and full mutation alleles
  • Accurately measures the methylation fraction for each FMR1 allele at higher resolution than Southern blot analysis
  • Provides increased sensitivity for the detection of lower abundance mosaic alleles
  • Includes spike-in digestion and amplification controls to ensure high performance with every sample
  • Designed to complement the AmplideX® FMR1 PCR Reagents
  • A more informative and convenient alternative to Southern Blot
  • Spike-in controls normalize results and report the success of the digestion reaction for each sample
  • Alleles are detected in both the FAM and HEX channels. A comparison of peak heights in the two channels is used to determine the methylation fraction for each allele
  • The methylation status observed using mPCR is concordant with Southern blot analysis
Further information is also available at the Asuragen-hosted FragileX-dedicated website ‘No More Southern Blots’ where a wealth of independent reviews, peer references and publications and archived webinars can be accessed and downloaded:
Latest News
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VH Bio Limited.
Registered in England & Wales, Number 2582192.
Registered Office: Unit 11B Station Approach, Team Valley Trading Estate, Gateshead, NE11 0ZF
Tel: +44 (0)191 495 8210 Fax: +44 (0)191 487 4285

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