Sequencing millions of ChIP-enriched DNA fragments using next generation sequencing technology enables cost-effective and precise analysis of the binding sites of transcription factors, replication and transcriptional machinery, structural proteins such as histones, as well as the impact of protein modifications on genome occupancy.

Hybridization-based methods are the most common method for genome-wide analysis of DNA-binding proteins (ChIP-chip), which combines chromatin immunoprecipitation with DNA microarrays.  The major limitation of this hybridization-based method is that microarrays are restricted to a fixed number of probes, thereby introducing bias.

Pricing is dependent on organism and desired project design. For further information please contact our Molecular Biology Product Manager, Catherine Mair (email: cmair@vhbio.com or tel: +44 (0)191 495 8211).