Successful Next Generation Sequencing is highly dependant on the quality of the initially used DNA samples. Size accuracy of the used DNA fragments and sample-to-sample consistency of the selected size range are fundamentally important factors in generating top quality starting material for Next Generation Sequencing. For both, the Next-Gen Prep Gel offers an ideal solution. Profiting from the well-proven high-resolution gel matrix of Elchrom’s Spreadex gels, the Next-Gen Prep Gel guarantees very accurate size discrimination. Similarly, the standardised and highly reproducible electrophoresis system of Elchrom Scientific minimises sample-to-sample variations during the extraction process. Furthermore, the gel matrix in Next-Gen Prep Gels is free of agarose and no chaotropic salts are used during extraction. Therefore the gel matrix is non-inhibitory to any downstream enzymatic reaction (e.g. ligases). Elchrom Scientific provides an easy-to-follow protocol that takes the user step-by-step through DNA-digestion, electrophoresis and extraction. Next-Gen Prep Gels are suitable for up to 20 μg of genomic DNA. The extraction procedure will generate recovery yields of up to 70 %. Next-Gen Prep Gels are ideal for all laboratories and customer service providers working with Next Generation Sequencing platforms such as Roche-454 GS FLX, Illumina Genome Analyzer and ABI SOLiD. Next-Gen Prep Gels are ideal for all laboratories and customer service providers working with Next Generation Sequencing platforms such as Roche-454 GS FLX, Illumina Genome Analyzer and ABI SOLiD.