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AmplideX® PCR/CE SMN1 Kit (RUO)

The AmplideX PCR/CE SMN1 Kit* provides a rapid, robust, and reliable method for the quantification of SMN1 exon 7 copy number from whole blood and buccal samples. With its streamlined PCR/CE workflow, rapid turnaround time, and automated results reporting software, the assay provides a simple and scalable SMN1 solution for all laboratories. Features & Benefits […]

The AmplideX PCR/CE SMN1 Kit* provides a rapid, robust, and reliable method for the quantification of SMN1 exon 7 copy number from whole blood and buccal samples. With its streamlined PCR/CE workflow, rapid turnaround time, and automated results reporting software, the assay provides a simple and scalable SMN1 solution for all laboratories.

Features & Benefits

AmplideX technology has become widely established for the detection and quantification of repeat expansions in a number of genes, including FMR1, C9orf72, and DMPK. With the AmplideX PCR/CE SMN1 Kit, this approach is applied to copy number resolution, allowing SMN1 exon 7 copy number to be estimated in under four hours using readily available laboratory equipment.

Reduced Complexity

  • Similar workflow to the AmplideX FMR1 kit eases implementation and testing
  • Scalable design allows for high-throughput testing
  • Automated analysis objectively reports copy number

Optimized Workflow

  • A simplified workflow compared to alternative methods
  • Fully kitted solutions with fewer QC and pipetting steps
  • DNA to data in under four hours with only 45 minutes of hands-on-time

Quality Performance

  • Ability to differentiate between 0, 1, 2, 3 and > 3 copies
  • Robust, reliable results with non-overlapping ratios for each copy number output
  • Concordance with previously characterized samples

Analytical Characteristics

Analytical characteristics of AmplideX PCR/CE SMN1 Kit:

  • Excellent concordance with previously characterized clinical samples (Figure 1)
  • Consistent results compared to other commercially available methods (Figure 2)
  • Automated results reporting via AmplideX Reporter software (Figure 3)

Figure 1. Excellent concordance with previously characterized clinical samples.

Figure 2: Consistent results compared to other commercially available methods.

Figure 3: Automated results reporting via AmplideX Reporter software.

Figure 4: Workflow for the AmplideX PCR/CE SMN1 Kit

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AmplideX® PCR/CE SMN1 Kit (RUO)
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