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CancerMaster Panel

The CancerMaster panel is designed to detect all variant types and the I-O markers, microsatellite instability (MSI) and tumor mutational burden (TMB), which are crucial biomarkers for cancer immunotherapy. For CNV analysis, a different cut-off is applied according to the ratio of cancer cells. The panel is also designed to detect Epstein-Barr virus (EBV) and […]

The CancerMaster panel is designed to detect all variant types and the I-O markers, microsatellite instability (MSI) and tumor mutational burden (TMB), which are crucial biomarkers for cancer immunotherapy. For CNV analysis, a different cut-off is applied according to the ratio of cancer cells. The panel is also designed to detect Epstein-Barr virus (EBV) and Human Papillomaviruses (HPV) allowing for comprehensive analysis of cancer-associated genes.

Key Features

Comprehensive Analysis of Cancer-Associated Genes

A broad range of targeting elements including somatic variants, IO-signatures (TMB, MSI), EBV and HPV, for clinical diagnoses of different cancer types and precision medicine.

Extensive Validation Studies

Robust panel performance is supported by extensive validation tests with reference samples and clinical specimens.

Specification

Gene count*524 genes
Covered regionsWhole CDS, custom regions of oncogenes, immune response genes, EBV and HPV viruses
Target size2.5Mb
Mutation typeSNV, indel, CNV, rearrangement, TMB, MSI, EBV, HPV
Sample typeFFPE, fresh-frozen tissue (> 50ng of fragmented DNA)
PlatformAll sequencers from Illumina, Thermo Fisher, MGI, Pac Bio and Oxford Nanopore
Bioinformatics pipelinePrimary, secondary and tertiary analysis result (FASTQ to VCF, VCF to clinical report)
PublicationMolecular Characterization of Biliary Tract Cancer Predicts Chemotherapy
and PD-1/PD-L1 Blockade Responses, Hepatology, 2021

*Gene add-on service: Genes can be added or removed according to customer needs

 

Panel Performance

The probes are designed to include the intron regions as well as clinically significant biomarkers. By conducting extensive validation studies with clinical samples, the panel was examined to show its performance with high sensitivity and specificity in detecting the variants in cancer-associated genes.

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Product Units Kit Format
CancerMaster Panel
20AICM16
Various All-In-One
CancerMaster Panel
20SICM16
Various Standard
CancerMaster Panel
20TICM16
Various Target Enrichment
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