Paroxysmal Nocturnal Haemoglobinuria (PNH) Screening

Product Description

FLAER is an Alexa Fluor® 488 labeled variant of aerolysin, a unique protein that binds tightly and specifically to mammalian GPI anchors. FLAER will not bind to PNH cells because they do not produce the anchor. Before FLAER, detection of PNH clones by flow cytometry relied on fluorescently labeled antibodies to GPI-linked proteins such as CD59 and CD55. These antibodies do not bind with high affinity, so that small PNH clones are not detected. Also, they Each screen for the absence of a specific protein, rather than loss of the GPI anchor, and therefore there is the risk of false negative results. Since FLAER binds to the GPI anchor itself, only PNH cells, which lack the anchor, will be negative. And since FLAER binds with high affinity, very small PNH populations can be detected.Login to see prices

Name Units Sku Price
25 µgCLFL1S-C£292.00
50 µgCLFL2S-C£505.00

2 in stock

25 µgCLFL1-C£292.00
50 µgCLFL2-C£505.00


There are no downloads for this product.

Our Suppliers

To shop by our suppliers, please click their logos.

Blog & News

Discover our Latest News and Insights


Find Instant Answers to Common Questions


Find us on the Road

Contact Us

Have a Question? Get in Touch!