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HLA Typing

Intermediate and high-resolution Human Leukocyte Antigen genotyping

Discuss your project

We perform Human Leukocyte Antigen (HLA) typing using two alternative methods to meet your requirements:

PCR-RSSO to provide intermediate-resolution HLA typing, and next-generation sequencing to provide high-resolution HLA typing.

We work in partnership with you

When you contact us, we begin a conversation to determine which level of HLA typing is best suited to your project and help you navigate through the complexity of the HLA genetic system.

  • We perform genotyping of the following Classical HLA genes: HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DPB1.
  • We accept a variety of different sample types, from cell lines to gDNA.
  • We deliver your results in as few as 48 hours
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Data reporting that is tailored to your needs

HLA typing data can be reported in a variety of different formats to suit your needs. Given the complexity of HLA nomenclature we welcome queries to help you better understand what your data means.

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Intermediate Resolution HLA typing

Performed by PCR-RSSO, this methodology offers a flexible solution:

  • Any number of samples / gene-sets can be processed, e.g. one sample for HLA-A.
  • PCR-RSSO is particularly cost-effective when typing selected HLA genes or ad hoc / low-throughout testing is required.
  • Results are delivered within 10 working days, but expedited HLA typing can be performed in as little as 48 hours.
  • HLA typing data can be reported in a variety of different formats to suit your needs.
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High Resolution HLA typing

Aims to unambiguously determine the amino acid sequence across the antigen-binding site of the HLA molecule where interaction with T lymphocytes occurs.

We perform high-resolution HLA typing by next-generation sequencing:

  • Our multi-gene approach provides HLA genotypes for all classical HLA genes in one single reaction.
  • High-resolution genotyping of all HLA genes requires only 50 ng gDNA.
  • Expedited HLA typing can be performed in as little as 10 working days.
  • HLA typing data can be reported in a variety of different formats to suit your needs.
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“VH Bio’s customer service is helpful, friendly, and professional.”
“We have been using the HLA Typing Services at VH Bio for over three years and have always found them to be very efficient and extremely helpful. Communication is excellent, with any queries being dealt with promptly and efficiently.”
“VH Bio is an excellent company for HLA typing and they always deliver the results ahead of time. I highly recommend them!”

Why Choose Us?

Quality-Assured Service

We are proudly accredited to the ISO 9001:2015 Quality Management standard and the ISO 14001:2015 Environmental Management standard.

Excellent Record of Performance

We participate in the relevant UK NEQAS external quality assessment programmes for Histocompatibility and Immunogenetics and maintain an excellent record of performance.

A highly competent Laboratory Services team

Over 35 Years Experience

State registered scientists and HLA Technical Specialists with a combined experience of 35+ years in Histocompatibility and Immunogenetics.

Qualified in Histocompatibility and Immunogenetics

Our team possess H&I qualifications including British Society for Histocompatibility and immunogenetics (BSHI) Diplomas and Associate membership of the Royal College of Pathologists.

All Results Validated

All results are validated by a scientist trained in good clinical practice and registered with The Health and Care Professionals Council (HCPC).

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