Adult Mouse BMAL1 Cell Lines

Cedarlane Adult Mouse BMAL1 Hypothalamic Neuron Cell Lines 

Immortalised Cell Lines for Studying Circadian Biology, Metabolic Regulation, and CNS Disorders 

Cedarlane’s Adult Mouse BMAL1 Cell Lines are immortalised hypothalamic neuron cultures derived from BMAL1+/+ (wild-type) and BMAL1−/− (knockout) C57BL/6J mice. Developed using proprietary platform technology, these lines were generated through retroviral transfer of SV40 T-antigen into primary hypothalamic cultures—providing researchers with robust in vitro models for dissecting the molecular underpinnings of circadian and metabolic regulation. 

 Key Features and Benefits 

• Derived from BMAL1 wild-type and knockout mice 

• Immortalised hypothalamic neurons for reproducible and long-term use 

• Express a wide and expanding range of neuropeptides, enzymes, and functional receptors 

• Enable in-depth studies of circadian rhythm, neuroendocrine function, and CNS-related disorders 

• Suitable for drug discovery, toxicology screening, and neurobiology research 

Research Applications 

These cell lines are ideal for investigating the role of BMAL1 and core circadian clock genes in the regulation of: 

• Circadian rhythm and sleep disorders 

• Neuropeptide signalling pathways 

• Obesity, diabetes, and metabolic syndrome 

• Hypertension and cardiovascular disease 

• Neuroendocrine dysfunction and CNS pathophysiology 

Referenced in Loganathan et al., Endocrinology, 2019, these cell lines have proven utility in studying endocrine disruptors, such as Bisphenol A, and their impact on clock gene expression and neuropeptide Y regulation. 

Reference Publication 

• Loganathan et al. (2019) Bisphenol A Alters Bmal1, Per2, and Rev-Erbα mRNA and Requires Bmal1 to Increase Neuropeptide Y Expression in Hypothalamic Neurons. Endocrinology.