Adult Mouse Hypothalamic Cell Lines

This product line is based on a proprietary platform technology which has enabled the creation of a series of immortalized hypothalamic neurons. Using CNTF (ciliary neurotrophic factor) to trigger neurogenesis, the cells were immortalized from two month old male (CLU170-CLU194) or two month old female (CLU450-CLU472) C57Bl/6 mice hypothalamic primary cultures by retroviral transfer of SV40 T-Ag. These cell lines have been found to express an ever expanding array of neuropeptides, enzymatic markers and biologically active receptors.
As such, these cell lines enable accurate in-vitro assays for use in the discovery, development and validation of new therapeutics targeted to central-nervous system diseases and disorders, including obesity, stress, and metabolic disorders, amongst others.