Mouse Glial Cell Lines

Cedarlane Mouse Glial Cell Lines 

Immortalised Glial Cells for CNS Drug Discovery, Neurodegenerative Research, and Neuroinflammation Studies 

Cedarlane’s Mouse Glial Cell Lines are a collection of immortalised glial cells derived from multiple brain regions of adult CD-1 mice. Developed using proprietary platform technology, these cell lines provide a powerful and reproducible in vitro system for investigating central nervous system (CNS) function, neurodegeneration, and glial-specific pathways. 

Product Overview 

• Source: Primary glial cultures isolated from the hypothalamus, cortex, and brainstem of adult CD-1 mice 

• Immortalisation Method: Retroviral transfer of SV40 T-antigen 

• Characterisation: Express a broad and expanding range of glial-specific markers, including GFAP 

• Designation: Region-specific glial cell lines for diverse neurobiological applications 

Key Features and Benefits 

• Reproducible models for studying astrocyte biology and glial cell function 

• Ideal for in vitro assays targeting obesity, neurodegenerative disorders, neuroinflammation, and other CNS-related conditions 

• Maintain region-specific glial characteristics from hypothalamic, cortical, and brainstem origins 

• Reduce variability and extend experimental timelines with stable, immortalised cultures 

• Compatible with molecular, cellular, and high-throughput screening assays 

Applications 

• Neurodegeneration and neuroinflammation research 

• Glial signalling and neuroimmune interactions 

• CNS drug discovery and toxicity screening 

• Obesity, energy balance, and metabolic studies 

• Astrocyte function and GFAP expression analysis 

Reference Publication 

Loganathan et al. (2024)
Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem
Read the full paper here